May in Tlaxcala averages a daily high of 28.1°C with nights around 10.2°C. Expect roughly 11.3 wet days totalling 71.8mm. Generally workable, with some weather to plan around.
Across the year, the best time to visit Tlaxcala is November–March.
Based on TLAXCALA DE XICONTECATL DGE, MX (0.6km), 1995–2024. 18 years of May data.