April in Des Moines averages a daily high of 17°C with nights around 5.1°C. Expect roughly 10.9 wet days totalling 95.9mm. Generally workable, with some weather to plan around.
Across the year, the best time to visit Des Moines is September.
Based on DES MOINES INTERNATIONAL AIRPORT, IA US (8.3km), 1995–2024. 30 years of April data.