May in Des Moines averages a daily high of 22.6°C with nights around 11.5°C. Expect roughly 12.7 wet days totalling 130.2mm. Comfortable conditions for being outdoors all day.
Across the year, the best time to visit Des Moines is September.
Based on DES MOINES INTERNATIONAL AIRPORT, IA US (8.3km), 1995–2024. 30 years of May data.