April in Winston-Salem averages a daily high of 21.8°C with nights around 9.4°C. Expect roughly 9.6 wet days totalling 90.1mm. Comfortable conditions for being outdoors all day.
Across the year, the best time to visit Winston-Salem is April–May.
Based on WINSTON SALEM REYNOLDS AIRPORT, NC US (4.1km), 1995–2024. 25 years of April data.