May in Winston-Salem averages a daily high of 25.5°C with nights around 14.1°C. Expect roughly 11.7 wet days totalling 98.2mm. Comfortable conditions for being outdoors all day.
Across the year, the best time to visit Winston-Salem is April–May.
Based on WINSTON SALEM REYNOLDS AIRPORT, NC US (4.1km), 1995–2024. 24 years of May data.