October in Winston-Salem averages a daily high of 21.7°C with nights around 10°C. Expect roughly 8.6 wet days totalling 80.1mm. Comfortable conditions for being outdoors all day.
Across the year, the best time to visit Winston-Salem is April–May.
Based on WINSTON SALEM REYNOLDS AIRPORT, NC US (4.1km), 1995–2024. 25 years of October data.